ABOUT ENHERTU

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What is ENHERTU?

ENHERTU is a prescription medicine used to treat adults with:

  • Human epidermal growth factor receptor 2 (HER2)-positive stage II or stage III early breast cancer followed by a taxane, trastuzumab and pertuzumab (THP) before surgery. Your healthcare provider will perform a test to make sure ENHERTU is right for you.

    • ENHERTU alone is a prescription medicine used to treat adults with:

  • HER2-positive early breast cancer who have received trastuzumab (with or without pertuzumab) and taxane-based treatment before surgery and have cancer remaining in the tissue removed during surgery.

It is not known if ENHERTU is safe and effective in children.

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How is ENHERTU thought to work?

As a targeted treatment called an antibody-drug conjugate (ADC), ENHERTU is designed to work differently than traditional chemotherapies.

Antibody graphic Antibody graphic

ENHERTU is made up
of an antibody with
the chemotherapy
attached

Antibody and cancer cell graphic Antibody and cancer cell graphic

The antibody part of
ENHERTU targets and
attaches to HER2 on
the cancer cell

The antibody part of ENHERTU
targets and attaches to HER2 on
the cancer cell

Cancer cell graphic Cancer cell graphic

ENHERTU enters
the cancer cell and the
chemotherapy is released

Destroy cancer cell graphic Destroy cancer cell graphic

The chemotherapy part
of ENHERTU helps
destroy the cancer cell
as well as other
cells nearby

Although ENHERTU is designed to target HER2 on cancer cells, it may affect some healthy cells. ENHERTU may not work for everyone.

How will I receive ENHERTU?

ENHERTU followed by THP is given as an intravenous infusion at your oncologist's office or at a nearby infusion center.

You will receive your THP infusions after completing your ENHERTU infusions.

Pill in hand Pill in hand

ENHERTU infusion is given 1 time every 3 weeks for a total of 4 infusions

Pre-infusion: Your healthcare provider will give you
medicines before your infusions to help prevent nausea
and vomiting.

Your first ENHERTU infusion will take about 90 minutes so the
healthcare provider can monitor for any potential reactions.

Future ENHERTU infusions should take about 30 minutes if your
first infusion was well tolerated.

First infusion – 90 minutesFirst infusion – 90 minutes

After completing
ENHERTU
infusions, THP is given 1 time every
3 weeks for a total of 4 infusions

Second infusion(s) – 30 minutes Second infusion(s) – 30 minutes

Surgery is performed after completing all ENHERTU and THP infusion sessions

If you miss a planned dose of ENHERTU, call your healthcare provider right away to schedule an appointment.
Do not wait until the next planned treatment cycle.

The goal of treatment before surgery is to help reduce the size of your tumor to make it easier to remove during surgery.

ENHERTU is given as an intravenous infusion at your oncologist's office or at a nearby infusion center.

First infusion – 90 minutes
Pill in hand Pill in hand

ENHERTU infusion is given 1 time every 3 weeks for a total of 14 infusions

Pre-infusion: Your healthcare provider will give you
medicines before your infusions to help prevent nausea
and vomiting.

Your first ENHERTU infusion will take about 90 minutes so the
healthcare provider can monitor for any potential reactions.

Future ENHERTU infusions should take about 30 minutes if your
first infusion was well tolerated.

If you miss a planned dose of ENHERTU, call your healthcare provider right away to schedule an appointment.
Do not wait until the next planned treatment cycle.

The goal of treatment after surgery is to help destroy any cancer cells that may
remain after surgery and help lower the chances of the cancer coming back.

THP, taxane-based chemotherapy (eg, paclitaxel), Herceptin® (trastuzumab), and pertuzumab.

Learn about ENHERTU4U

Review the results

See clinical trial results
before surgery
See clinical trial results
after surgery