About ENHERTU

About ENHERTU

Understanding HER2+ unresectable or metastatic
breast cancer

What is HER2?
HER2 is a protein that tells cells to grow. In HER2 positive breast cancer, the cancer cells have too much HER2, which leads to cancer growth.

These cells grow and divide faster than other healthy cells, causing tumors to form.

In metastatic breast cancer, the cancer has spread to other parts of the body. Unresectable breast cancer means it can't be removed by surgery.

Understanding ENHERTU

Understanding
ENHERTU

What is ENHERTU?

ENHERTU is a prescription medicine used in adults to treat human epidermal growth factor receptor 2 (HER2)-positive breast cancer that cannot be removed by surgery or that has spread to other parts of your body (metastatic), and who have received two or more prior anti-HER2 breast cancer treatments.
It is not known if ENHERTU is safe and effective in children.

ENHERTU was FDA approved for this use based on a clinical study that measured how many patients responded and how long they responded. ENHERTU is still being studied to confirm these results. It is not known if ENHERTU is safe and effective in children.

How ENHERTU works

ENHERTU is made up of two cancer-fighting agents: an antibody attached to chemotherapy.

  • ENHERTU works by attacking HER2+ cancer cells and delivering chemotherapy to them
  • Although ENHERTU is designed to target HER2+ cancer cells it may still affect some healthy cells

How will I receive my ENHERTU treatment?

ENHERTU is given 1 time every three weeks (21-day treatment cycle) in a hospital or clinic into your vein through an intravenous (IV) line by your healthcare provider.

Your healthcare provider will decide how many treatments you need

  • If you experience infusion related symptoms, your healthcare provider may slow, interrupt, or stop your treatment
  • If you experience infusion related symptoms, your healthcare provider may slow, interrupt, or stop your treatment
  • Call your healthcare provider right away if you miss an appointment

How long do the infusions take?

Your healthcare provider may change or stop your dose
of ENHERTU if you experience side effects

Your healthcare provider
may change or stop your
dose of ENHERTU if you
experience side effects

ENHERTU clinical study

ENHERTU was studied in 184 females with HER2+ unresectable or metastatic breast cancer who had previously been treated with two or more prior anti-HER2 therapies.

  • Half of the patients in this study had received 5 or more prior drugs for metastatic breast cancer before starting ENHERTU

ENHERTU helped shrink tumors in over half of the patients in the clinical study

Six out of ten patients (60.3%) had a response to ENHERTU treatment, meaning the tumor shrank in size by at least 30%. This is called an objective response rate (or ORR).

  • Some people (8 or 4.3%) achieved what is called a complete response (or CR), which means that the tumor shrank to the point where the healthcare provider was no longer able to detect it through tests known as imaging
  • The majority of people (103 or 56%) taking ENHERTU achieved some tumor shrinkage called a partial response (or PR)

ENHERTU kept working for nearly 15 months

While the length of time varied, ENHERTU kept working for a median of 14.8 months in patients who responded to treatment.

For the 111 patients who responded to treatment, the length of time that they maintained their response to ENHERTU is called the duration of response (DOR).

HER2 stands for human epidermal growth factor receptor 2; mBC stands for metastatic breast cancer.

Some people may have side effects when taking ENHERTU

ENHERTU can cause serious side effects. See "What is the most important information I should know about ENHERTU?"
The most common side effects of ENHERTU include:

  • Nausea
  • Feeling tired
  • Vomiting
  • Hair loss
  • Constipation
  • Decreased appetite
  • Low red blood cell counts
  • Low white blood cell counts
  • Diarrhea
  • Cough
  • Low platelet counts

ENHERTU may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of ENHERTU. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please click here for full Prescribing Information, including Boxed WARNING, and click here for Medication Guide.

Ready to learn more about ENHERTU?